The GnRH neuron and its control / editors, Allan E. Herbison & Tony M. Plant.

Historical introduction to the GnRH neuron. The framework upon which current research on the GnRH neuron and its control is built / Tony M. Plant, Allan E. Herbison -- GnRH neuron development. Prenatal development of GnRH neurons / Yufei Shan, Susan Wray -- Fetal/perinatal programming causing sexual dimorphism of the Kisspeptin-GnRH neuronal network / Hiroko Tsukamura, Kei-ichiro Maeda, Yoshihisa Uenoyama -- Postnatal development of GnRH neuronal function / Ei Terasawa -- GnRH neuron biology. Regulation of GnRH gene expression / Hanne M. Hoffmann, Pamela L. Mellon -- Morphology of the adult GnRH neuron / Rebecca E. Campbell -- The anatomy of the GnRH neuron network in the human / Katalin Skrapits, Erik Hrabovszky -- Electrophysiology of rodent GnRH neurons / Richard Piet, Allan E. Herbison -- Anatomy and physiology of GnRH neurons and their control of pituitary function in fish / Yoshitaka Oka -- Regulation of GnRH neuron function. Unveiling the importance of glia and vascular endothelial cells in the control of GnRH neuronal function / Vincent Prevot, Ariane Sharif -- Genetic strategies examining Kisspeptin regulation of GnRH neurons / Michael Candlish, Philipp Wartenberg, Ulrich Boehm -- KNDy hypothesis for generation of GnRH pulses: Evidence from sheep and goats / Robert L. Goodman, Satoshi Okhura, Hiroaki Okamura, Lique M Coolen, Michael N Lehman -- Generation of the GnRH surge and LH surge by the positive feedback effect of estrogen / Iain Clarke -- Influence of stress on the GnRH neuronal network / Pasha Grachev, Kevin T. O'Byrne -- Metabolic regulation of GnRH neurons / Maggie C. Evans, Greg M. Anderson -- Seasonal control of the GnRH neuronal network as a means of uncovering novel central mechanisms governing mammalian reproduction / Sébastien Milesi, Paul Klosen, Valerie Simonneaux -- GnRH in the clinic. Human genetics of GnRH neuron function / A. Kemal Topaloglu, L. Damla Kotan -- Modulators of GnRH secretion and therapeutic applications / Claire L. Newton, Ross C. Anderson, Robert P. Millar.

Includes bibliographical references and index.

"The GnRH Neuron and its Control examines the developmental biology of GnRH neurons including their birth in the nasal placode of the early embryo, perinatal programming, and sexual differentiation, in addition to the hypothalamic mechanisms that control GnRH neurons in adulthood to generate pulsatile and surge modes of GnRH secretion throughout the major life stages including aging. The morphology, electrophysiology, signal transduction pathways, transcriptional regulators, and genomics underlying function of the adult GnRH neuron is discussed in detail, as is the neuroendocrinology and cell biology governing the generation of both modes of GnRH release. The book also reviews the neurobiological mechanisms and circuitry responsible for the modulation of the activity of GnRH neurons by season, stress, nutrition, and metabolism, and covers the current and potential therapeutic approaches to regulating GnRH secretion and action. Filled with newly identified research and classical fundamental knowledge to GnRH biology, it will provide students, researchers, and practitioners with an in-depth understanding of reproductive neuroendocrinology."--Publisher's description.

Online resource; title from digital title page (viewed on April 19, 2018).