Mitochondrial dysfunction caused by drug and environmental toxicants / edited by Yvonne Will, James A. Dykens.

Includes bibliographical references and index.

Description based on print version record and CIP data provided by publisher.

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. Front Matter -- Contributions of Plasma Protein Binding and Membrane Transporters to Drug-Induced Mitochondrial Toxicity / Gavin P McStay -- The Role of Transporters in Drug Accumulation and Mitochondrial Toxicity / Kathleen M Giacomini, Huan-Chieh Chien -- Structure-Activity Modeling of Mitochondrial Dysfunction / Steve Enoch, Claire Mellor, Mark Nelms -- Mitochondria-Targeted Cytochromes P450 Modulate Adverse Drug Metabolism and Xenobiotic-Induced Toxicity / Haider Raza, F Peter Guengerich, Narayan G Avadhani -- Mitochondrial Dysfunction in Drug-Induced Liver Injury / Annie Borgne-Sanchez, Bernard Fromenty -- Evaluating Mitotoxicity as Either a Single or Multi-Mechanistic Insult in the Context of Hepatotoxicity / Amy L Ball, Laleh Kamalian, Carol E Jolly, Amy E Chadwick -- Cardiotoxicity of Drugs / Zoltan V Varga, Pal Pacher -- Skeletal Muscle Mitochondrial Toxicity / Eric K Herbert, Saul R Herbert, Karl E Herbert -- Manifestations of Drug Toxicity on Mitochondria in the Nervous System / Jochen H M Prehn, Irene Llorente-Folch -- Nephrotoxicity / Ana Belén Sanz, Maria Dolores Sanchez-Niño, Adrian M Ramos, Alberto Ortiz -- Mammalian Sperm Mitochondrial Function as Affected by Environmental Toxicants, Substances of Abuse, and Other Chemical Compounds / Sandra Amaral, Renata S Tavares, Sara Escada-Rebelo, Andreia F Silva, João Ramalho-Santos -- Biological and Computational Techniques to Identify Mitochondrial Toxicants / Robert B Cameron, Craig C Beeson, Rick G Schnellmann -- The Parallel Testing of Isolated Rat Liver and Kidney Mitochondria Reveals a Calcium-Dependent Sensitivity to Diclofenac and Ibuprofen / Sabine Schulz, Sabine Borchard, Tamara Rieder, Carola Eberhagen, Bastian Popper, Josef Lichtmannegger, Sabine Schmitt, Hans Zischka -- In Vitro Methodologies to Investigate Drug-Induced Toxicities / Rui F Simões, Teresa Cunha-Oliveira, Cláudio F Costa, Vilma A Sardão, Paulo J Oliveira -- Combined Automated Measurement of Respiratory Chain Complexes and Oxidative Stress / Marc Conti, Thierry Delvienne, Sylvain Loric -- Measurement of Mitochondrial Toxicity by Flow Cytometry / Padma Kumar Narayanan, Nianyu Li -- MitoChip / Varsha G Desai, G Ronald Jenkins -- Using 3D Microtissues for Identifying Mitochondrial Liabilities / Simon Messner, Olivier Frey, Katrin Rössger, Andy Neilson, Jens M Kelm -- Toward Mitochondrial Medicine / David A Dunn, Michael H Irwin, Walter H Moos, Kosta Steliou, Carl A Pinkert -- Measurement of Oxygen Metabolism In Vivo / M P J Diemen, R Ubbink, F M Münker, E G Mik, G J Groeneveld -- Detection of Mitochondrial Toxicity Using Zebrafish / Sherine S L Chan, Tucker Williamson -- MiRNA as Biomarkers of Mitochondrial Toxicity / Terry R Vleet, Prathap Kumar Mahalingaiah -- Biomarkers of Mitochondrial Injury After Acetaminophen Overdose / Benjamin L Woolbright, Hartmut Jaeschke -- Acylcarnitines as Translational Biomarkers of Mitochondrial Dysfunction / Richard D Beger, Sudeepa Bhattacharyya, Pritmohinder S Gill, Laura P James -- Mitochondrial DNA as a Potential Translational Biomarker of Mitochondrial Dysfunction in Drug-Induced Toxicity Studies / Afshan N Malik -- Predicting Off-Target Effects of Therapeutic Antiviral Ribonucleosides / Jamie J Arnold, Craig E Cameron -- Imaging of Mitochondrial Toxicity in the Kidney / Andrew M Hall, Joana R Martins, Claus D Schuh -- Imaging Mitochondrial Membrane Potential and Inner Membrane Permeability / Anna-Liisa Nieminen, Venkat K Ramshesh, John J Lemasters -- Quantifying Skeletal Muscle Mitochondrial Function In Vivo by 31P Magnetic Resonance Spectroscopy / Graham J Kemp -- Supplemental Images -- Front Matter -- Statin and Fibrate-Induced Dichotomy of Mitochondrial Function / Viruna Neergheen, Alex Dyson, Luke Wainwright, Iain P Hargreaves -- Friend or Foe / Sofia Annis, Adeel Safdar, Eduardo Biala, Ayesha Saleem, Housaiyin Li, Priya Gandhi, Zoe Fleischmann, Carmen Castaneda-Sceppa, Jonathan L Tilly, Dori C Woods, Konstantin Khrapko -- Involvement of Mitochondrial Dysfunction on the Toxic Effects Caused by Drugs of Abuse and Addiction / Daniel José Barbosa, João Paulo Capela, Maria Lourdes Bastos, Félix Carvalho -- Drug-Induced Mitochondrial Toxicity during Pregnancy / Diana Luz Juárez-Flores, Ana Sandra Hernández, Laura García-Otero, Mariona Guitart-Mampel, Marc Catalán-García, Ingrid González-Casacuberta, Jose César Milisenda, Josep Maria Grau, Francesc Cardellach, Constanza Morén, Glòria Garrabou -- Mitochondrial Toxicity in Children and Adolescents Exposed to Antiretroviral Therapy / Antoni Noguera-Julian, Eneritz Velasco-Arnaiz, Clàudia Fortuny -- Drug-Induced Mitochondrial Cardiomyopathy and Cardiovascular Risks in Children / Neha Bansal, Mariana Gerschenson, Tracie L Miller, Stephen E Sallan, Jason Czachor, Hiedy Razoky, Ashley Hill, Miriam Mestre, Steven E Lipshultz -- Role of Mitochondrial Dysfunction in Linezolid-Induced Lactic Acidosis / Alessandro Santini, Dario Ronchi, Daniela Piga, Alessandro Protti -- Metformin and Lactic Acidosis / Jean-Daniel Lalau -- Lessons Learned from a Phase I Clinical Trial of Mitochondrial Complex I Inhibition / Cecilia C Low Wang, Jeffrey L Galinkin, William R Hiatt -- Pharmacological Activation of Mitochondrial Biogenesis for the Treatment of Various Pathologies / Whitney S Gibbs, Natalie E Scholpa, Craig C Beeson, Rick G Schnellmann -- Mitochondrial Toxicity Induced by Chemotherapeutic Drugs / Luciana L Ferreira, Ana Raquel Coelho, Paulo J Oliveira, Teresa Cunha-Oliveira -- The Mitochondrial Exposome / Douglas I Walker, Kurt D Pennell, Dean P Jones -- Central Mitochondrial Signaling Mechanisms in Response to Environmental Agents / Young-Mi Go, Karan Uppal, Dean P Jones -- Detection of Mitochondrial Toxicity of Environmental Pollutants Using Caenorhabditis elegans / Laura L Maurer, Anthony L Luz, Joel N Meyer -- Persistent Organic Pollutants, Mitochondrial Dysfunction, and Metabolic Syndrome / Hong Kyu Lee, Youngmi Kim Pak -- Cigarette Smoke and Mitochondrial Damage / Jalal Pourahmad, Marjan Aghvami, Mohammad Hadi Zarei, Parvaneh Naserzadeh.