Cellular signal transduction in toxicology and pharmacology : data collection, analysis, and interpretation / edited by Jonathan W. Boyd (West Virginia University, Morgantown, WV, US), Richard R. Neubig (Michigan State University, MI, US).

Includes bibliographical references and index.

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Intro; Title Page; Copyright Page; Contents; List of Contributors; About the Editors; Preface; Chapter 1 Introduction to Cellular Signal Transduction: The Connection Between a Biological System and Its Surroundings; 1.1 Starting Big, but Ending Small; 1.1.1 Key Features of Signal Transduction; 1.2 Responding to Our Environment: Sensory Perception Begins and Ends with Signal Transduction; 1.2.1 Taste (Gustation); 1.2.2 Smell (Olfaction); 1.2.3 Sight (Vision); 1.2.4 Sound (Audition); 1.2.5 Touch (Somatosensation); 1.3 Primary Transport Systems Involved in Signal Transduction

1.3.1 Ion Channels, Transporters, and Ion Pumps1.3.2 Receptors; 1.3.3 Endocytosis; 1.3.4 Exosomes; 1.4 Key Organelles Involved in Signal Transduction; 1.4.1 Mitochondria; 1.4.2 Endoplasmic Reticulum; 1.4.3 Nucleus; References; Chapter 2 Mechanisms of Cellular Signal Transduction; 2.1 Posttranslational Modifications and Their Roles in Signal Transduction; 2.1.1 Phosphorylation; 2.1.2 Acylation; 2.1.3 Alkylation; 2.1.4 Glycosylation; 2.1.5 Other PTMs; 2.2 Receptors; 2.3 Receptor Signaling Mechanisms; 2.3.1 Basic Principles of Signal Transduction Mechanisms; 2.3.1.1 Selectivity and Recognition

2.3.1.2 Flexible Modularity2.3.1.3 Molecular Switches; 2.3.1.4 GPCRs and Second Messengers; 2.3.1.5 Amplification; 2.3.1.6 Turn-Off Mechanisms; 2.3.1.7 Localization; 2.3.1.8 Biased Signaling/Functional Selectivity; 2.4 Receptor Tyrosine Kinases; 2.5 Steroid Receptors; 2.6 Reactive Oxygen Species (ROS); 2.7 Summary; References; Chapter 3 From Cellular Mechanisms to Physiological Responses: Functional Signal Integration Across Multiple Biological Levels; 3.1 Introduction; 3.2 Cellular Information Flow: Mechanisms of Cellular Signal Integration and Regulation

Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques